Best serum for mature skin in men

Kiehl's Age Defender Power Serum is the most effective pick for mature skin in men. Its lead ingredient, hydroxypropyl tetrahydropyrantriol, better known as Pro-Xylane, is a sugar-derived ingredient used to help skin look firmer and more resilient. Hydrolyzed soy and rice proteins leave a light film that helps skin look smoother, adenosine is commonly used to soften the look of wrinkles, and caffeine adds antioxidant support. Glycerin, high on the ingredient list, draws water into the skin to keep it hydrated. The lightweight fluid texture absorbs quickly, which suits men who don't like a heavy feel on their skin. Apply a few drops to clean skin morning and evening, before moisturizer, and wear sunscreen during the day, since daily sun protection is key to preventing new lines. The formula contains denatured alcohol and fragrance, so if your skin is sensitive, patch test it on a small area first.

Option	Product	Price	Price per use	Days to results	Compared with most effective
Most effective	Kiehl’s Age Defender Power Serum	US$80 (100 mL)		28

Why it works

Hyaluronic acid and glycerin (humectants)

Humectants are moisturizer ingredients that draw water into the outer layer of skin and hold it there. Glycerin is regarded as the most effective humectant for hydrating the skin surface. Hyaluronic acid, a molecule the skin also makes naturally, is another humectant that dermatologists list for dry skin. Used on their own, humectants can pull water out of the skin into dry air and may even increase water loss, which is why well-made moisturizers pair them with occlusive ingredients that seal water in. They work best applied to damp skin after bathing.

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Sources

Reviewed by Emilie Sydney-Smith

Updated 2026-10-31